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When used alone, statins cause rhabdomyolysis in less than one percent of patients. In series of subsequent steps, VLDLs are transformed into intermediate density lipoproteins IDLs and cholesterol-rich low density lipoproteins LDLs. No effect was observed on the pharmacokinetics of pravastatin or its isomeric metabolite SQ 31,906. Preliminary data suggest that the pravachol aus indien addition of either probucol or gemfibrozil to therapy with lovastatin or pravastatin is not associated with greater reduction in LDL-cholesterol than that achieved with lovastatin or pravastatin alone.
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