Gender: single-dose study involving 12 healthy male and 12 healthy female volunteers revealed no online wellbutrin kjop sex-related differences in the pharmacokinetic parameters of bupropion. Precautions General Agitation and Insomnia Increased restlessness, agitation, anxiety, and insomnia, especially shortly after initiation of treatment, have been associated with treatment with bupropion. Patients should be advised that they may notice in their stool something that looks like tablet. Given the wide variability among individuals and their capacity to metabolize and eliminate drugs this disproportionate increase in seizure incidence with dose incrementation calls for caution in dosing. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your health care professional. Patients should be told that any CNS-active drug like Wellbutrin XL Tablets may impair their ability to perform tasks requiring judgment or motor and cognitive skills.