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The oral LD50 of amiloride HCl calculated as the base is 56 mg kg in mice and 36 to 85 mg kg kobe moduretic narkotika in rats, depending on the strain. This medication may cause too much body water and salts to be lost dehydration. This site does not dispense medical advice or advice of any kind. MedicineNet does not provide medical advice, diagnosis or treatment.