How Should Nexium Be Stored? Nexium should be stored at room temperature. Drug interaction studies have shown that esomeprazole does not have any clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin. Symptoms of overdose may include confusion, extreme sweating, blurred vision, or unusually fast heartbeat. Esomeprazole is completely eliminated from plasma and there is no accumulation during once daily administration. The most frequently occurring adverse reactions in all three groups were headache. In clinical trials using combination therapy with NEXIUM plus amoxicillin and clarithromycin, no additional increased laboratory abnormalities kjope nexium uten et kredittkort particular to these drug combinations were observed. Dose reduction of saquinavir should be considered from the safety perspective for individual patients.